The Illumina annotated gene set, which included a larger number of genes annotated to more MSDP-associated CpGs, was additionally enriched with numerous pathways involving growth factor signaling (FGFR, EGF-EGFR, and PDGFR), hormones (aldosterone, insulin, and TSH), immune and inflammatory signaling (IL2 and IL6), MAPK signaling, myometrial and vascular smooth muscle contraction, signal transduction, and cancer pathways. The gene discussed is INS; the disease is cancer.