SS18, SSX1, and another SWI/SNF complex member TLE142 are elevated in 3 PDX models (16 samples) by SS18-SSX1 fusions in SARC, as key target genes AXIN2, MYC, and CCND1 in the Wnt pathway43 and IGFB2 and IGF244 for IGF driven tumor genesis (Fig. 4c, right panel). The gene discussed is SSX1; the disease is neoplasm.