AXIN2 and neoplasm: SS18, SSX1, and another SWI/SNF complex member TLE142 are elevated in 3 PDX models (16 samples) by SS18-SSX1 fusions in SARC, as key target genes AXIN2, MYC, and CCND1 in the Wnt pathway43 and IGFB2 and IGF244 for IGF driven tumor genesis (Fig. 4c, right panel).