More recently, it has also been shown in monocytes and pDCs that LAIR1 cross-linking or binding to cognate ligands collagen and C1Q can inhibit the production of IFNα in response to Toll-like receptor ligands in healthy controls and patients with systemic lupus erythematosus (42, 43). Here, IFNA1 is linked to systemic lupus erythematosus.