ITGA2 and COVID-19: In contrast, LAIR1, a collagen receptor (32, 33) and a type 1 Ig containing two immunoreceptor tyrosine-based inhibitory motifs (34), was most differentially up-regulated in myeloid cell types of critical COVID-19+ cases compared to healthy controls (cM, ncM, and cDC: log2FC = 0.51 to 0.97, Padjusted = 4.8 × 10−3 to 3.9 × 10−5) and compared to moderate-severe COVID-19+ cases (cM and ncM: log2FC = 0.47 to 0.50, Padjusted = 1.2 × 10−2 to 7.9 × 10−3; Fig. 4B and fig.