Leading to these findings, it was demonstrated that ectopically expressing mouse GSDME (mGSDME) in murine 4T1E breast cancer cells engrafted into immunocompetent BALB/c mice significantly inhibited 4T1E tumor growth and led to an increase in the infiltration of NK cells and tumor-associated macrophages (TAMs) [33]. Here, GSDME is linked to neoplasm.