GSDME and neuroblastoma: Through further investigation, it was shown that the human NK cell line YT can activate pyroptosis in GSDME-expressing HeLa cells and speculated from experiments using the human neuroblastoma SH-SY5Y cell line that this induction was achieved through GzmB, which not only cleaves GSDME at the same site as caspase-3 but indirectly activates caspase-3.