In human cancer cell lines endogenously expressing GSDMB, specifically OE19 (esophageal carcinoma), SW837 (CRC), and SKCO1 (CRC), it was further shown that GzmA delivery through electroporation or perforin was sufficient to induce GSDMB-mediated pyroptosis [35]. This evidence concerns the gene GZMA and colorectal carcinoma.