HMGB1 and neoplasm: In addition to increased IL-1β, IL-18, and HMGB1 serum and tumor levels, numerous immunostimulatory and antitumor effector genes (e.g., Cd69, Gzma, Gzmb) were found to be upregulated and various immunosuppressive and protumor genes (e.g., Csf1, Vegfa, Cd274) downregulated in the 4 T1 tumors treated with NP–Gsdma3 and Phe-BF3 in BALB/c mice [70].