SLC12A1 and acute kidney tubular necrosis: The mechanisms by which this balanced forced-diuresis, in the RG group, would protect the kidneys is not entirely clear but could be related to the fact that furosemide prevents renal hypoxia at the level of loop of Henle by inhibiting the sodium potassium chloride co-transporter (NKCC2) channels present on the apical membrane of the thick ascending limb (TAL) [19] whilst the forced-diuresis prohibits the build-up of casts within the renal tubules which is well recognized in acute tubular necrosis.