Moreover, we showed that apatinib inhibited proliferation and induced apoptotic and autophagic death in lung cancer tumors, as evidenced by the decreased expression of Cyclin D1, Nrf2 and p62, but the increased expression of Cleaved Caspase 3 and LC3-II (Fig. 7f-i). The gene discussed is CASP3; the disease is lung carcinoma.