We noted that apatinib not only inhibited IL-6-mediated upregulation of phosphorylated STAT3 and PD-L1 in NSCLC cells, but also suppressed PD-L1 activation in THP-1- derived macrophages which were stimulated by CM from A549 and H1299 cells. The gene discussed is STAT3; the disease is non-small cell lung carcinoma.