In previous reported studies, by using the single/double or triple polymorphism approach, VEGF −2578C/A, −2549I/D, −460T/C, +405C/G, −7C/T and +936C/T polymorphisms have been analyzed to evaluate their potential association with breast cancer risk in different ethnic groups and results are conflicting (Additional file 1: Table S2). This evidence concerns the gene VEGFA and breast cancer.