The AA genotype and A allele of VEGF −2578C/A, II genotype and I allele of VEGF −2549I/D, CC genotype and C allele of VEGF −460T/C, GG genotype and G allele of VEGF +405C/G polymorphism was significantly associated with increased risk of breast cancer. The gene discussed is VEGFA; the disease is breast carcinoma.