We then treated HCC cells with autophagy inhibitor 3‐methyladenine (3‐MA) and found that the protein levels of Dvl2 were significantly restored at 6 h in ASPM‐silenced SMMC‐7721 cells and at 4 h in ASPM‐silenced HepG2 cells (Fig. 7B), suggesting that Dvl2 decrease in ASPM‐deficient HCC cells may involve an autophagy‐dependent pathway. Here, DVL2 is linked to hepatocellular carcinoma.