Moreover, the mice with silicosis following treatment of miR‐205‐5p agomir showed upregulated expression patterns of Col1a1, Col3a1 and LC3, while this upregulation was annulled by Lenti‐E2F1, Lenti‐SKP2 or siBeclin1 (Figure 7C,D, Supplementary Figure 1B,C). Here, E2F1 is linked to silicosis.