Consistent with an earlier induction of HCC in the mutant mice, tumors found in 6-month-old Ku703A/3A mice were significantly larger (21.42 ± 7.53 mm3) than those found in Ku70+/+ mice (0.91 ± 0.34 mm3) (Figure 4C). Here, XRCC6 is linked to hepatocellular carcinoma.