Several older reports have claimed thatphase II reactions areless affected by HI than oxidative phase I reactions.40−42 We now show that the expression of several UGTs, such as UGT1A6,1A9, 2B4, and 2B7, is significantly (to the same degree as CYP enzymes)impaired by cirrhosis, especially in moderate to severe stages. The gene discussed is PPIG; the disease is Cirrhosis.