Cancer and/or non-alcoholicfatty liver disease-related cirrhosis showed larger deteriorationin levels of CYP3A4, 2C8, 2E1, 1A6, UGT2B4/7, CES1, FMO3/5, EPHX1,MGST1/3, BSEP, and OATP2B1 than the cholestasis set. The gene discussed is EPHX1; the disease is cholestasis.