Targets affected only by NAFLD-associated cirrhosis were CYP2C8,MGST1, MGST3, UGT2B4, FMO5, and BSEP, while targets that showed asignificant reduction only with cancer-associated cirrhosis were CYP2E1and UGT1A6. The gene discussed is CYP2C8; the disease is metabolic dysfunction-associated steatotic liver disease.