Having confirmed the gene silencing effect and tumor targeting ability of the UCNP-siRNA-PAA-AS1411 nanocages, we assumed that the UCNP-siRNA-PAA-AS1411 could effectively hinder lung tumor growth through silencing the VEGF protein in NCI-H889 lung tumor cells, thus prolonging the survival of mice. The gene discussed is VEGFA; the disease is neoplasm.