The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH) in 2014 selected calcium channel blockers (CCBs), angiotensin II receptor blockers (ARBs), angiotensin‐converting enzyme inhibitors (ACEi), and diuretics as the first‐choice drugs for hypertensive patients without compelling indications.1 This evidence concerns the gene ACE and hypertensive disorder.