A cautious interpretation of this finding is of course mandatory, due to the lack of significance for the role of that gene region on cancer onset at the multivariate analysis, to the possibility of a type 1 statistical error for multiple testing and to the obvious need of confirmation by larger, independent series, taking into account all the NF1 gene mutation burden and not limiting the analysis to the recurrent variants only, like in the present study. This evidence concerns the gene NF1 and cancer.