When the variants were grouped according to their NF1 gene region, those located in the 5′ end preceding the first protein domain (Figure 1) showed a significantly lower age‐specific tumor burden compared to all the other domains together (Figure 3), consistent with the model of other oncosuppressors like the APC gene, which causes an attenuated polyposis in carriers of pathogenic variants at the 5′ end.46 The gene discussed is APC; the disease is neoplasm.