NF1 and neurofibromatosis type 1: Neurofibromatosis type I is a long‐standing model of clinical and genetic variability, which is due to the pleiotropic expression and to the mutational pattern of the NF1 gene13, 15 and is characterized by the frequent occurrence of de novo variants and their dispersion through the whole gene, with only few preferential locations or mechanisms.1, 4