Previous studies found on the one hand a significant reduction of naïve CD28 + CD4 + T cells in AD patients [23, 24] and a decreased number of CD28 + CD3 + in VD [25], on the other hand an increase in CD28 + CD8 + and CD28 + CD4 + T cells were observed in AD patients [26, 27]. Here, CD8A is linked to sexually transmitted disease.