On this note, elevated oxidative stress has been shown to promote liver fibrosis by stimulating the generation of collagen from the activated hepatic stellate cells and release of other profibrotic (TGF-β, α-SMA), chemotaxis (MCP-1) and proinflammatory (IL-1β, TNF-α) mediators [38]. This evidence concerns the gene ACTA1 and Hepatic fibrosis.