In the present study, mice lacking the genes for TNF‐α receptors (TNFR1KO and TNFR2KO) also developed hypertension in response to 4 weeks of AngII treatment plus HS intake; however, it is interesting that the TNFR1KO mice showed a greater hypertensive response compared to that observed in WT mice or in TNFR2KO mice. Here, AGT is linked to hypertensive disorder.