PPARGC1A and Cachexia: Similarly, treatment with AICAR (Pigna et al., 2016) or trimetazidine (Molinari et al., 2017), which are considered “exercise mimetics” that upregulate PGC‐1α, was shown to partially restore muscle mass and myofiber cross‐sectional area in C26 mice, suggesting that the induction of PGC‐1α is crucial for exercise‐induced alleviation of muscle mitochondrial dysfunction in cancer cachexia.