Although obesity in PCOS girls improved significantly after first-line treatment with weight management, FSH (before group: 5.91±0.12 vs. after group: 5.39 ± 2.60), LH (before group: 6.30 ± 0.64 vs. after group: 7.26 ± 3.40), and E2 (before group: 56.10 ± 15.23 vs. after group: 61.17 ± 2.78) were similar to those before weight intervention without statistically significant differences (P>0.05) (Table 2). Here, BRD2 is linked to obesity due to melanocortin 4 receptor deficiency.