Interestingly, in cases where it has been tested, such as Cenpj- or Cep63-deficient mice, the reduced cortical thickness was fully rescued by co-deletion of Trp53, identifying p53-dependent apoptotic cell death as main driver of microcephaly in these models (Insolera et al., 2014; Marjanović et al., 2015). The gene discussed is TP53; the disease is microcephaly.