TP53 and microcephaly: Previous work found that impairment of centrosomal microtubule nucleation in apical progenitors slowed mitotic spindle assembly and progression, leading to p53-dependent apoptosis and causing microcephaly (Insolera et al., 2014; Lin et al., 2020; Marjanović et al., 2015; McIntyre et al., 2012; Novorol et al., 2013).