To determine the suitability of Lphn3−/− (KO) rats as a prospective animal model of ADHD and assess their relative degree of impairment, we also report “positive control” measures of the same behaviors in Spontaneously Hypertensive Rats (SHRs) as numerous studies have shown their utility as an animal model of ADHD.55–59 In line with previous research, we expected to find an overall deficit in both impulsive action and working memory in the SHRs relative to Wistar-Kyoto (WKY) rats (i.e., the SHR control strain) as well as in the Lphn3 KO rats relative to their Lphn3+/+ (WT) controls. The gene discussed is ADGRL3; the disease is hypertensive disorder.