Research in animal models has provided converging evidence that the Lphn3 gene plays a role in EDs.34 For example, Lphn3−/− knockout (KO) mice exhibit hyperactivity in the open field test, increased premature responses (indicative of impulsivity) on a continuous performance test, and are more sensitive to the locomotor stimulant effects of cocaine.35,36 Similarly, Lphn3 KO rats were also hyperactive,37 while zebrafish that lacked lphn3.1 (one of two lphn3 zebrafish orthologs) exhibited increased locomotion, nighttime hyperactivity, and episodes of motor impulsivity.38 The gene discussed is ADGRL3; the disease is Ehlers-Danlos syndrome.