ADGRL3 and Ehlers-Danlos syndrome: Numerous studies have implicated Lphn3 in the etiology of ADHD.17,20–24,26–32 While less is known about whether Lphn3 contributes to the cause of other EDs, there is some evidence suggesting this is the case.13,25,33,69 Future research in our lab will assess whether differences in drug self-administration (as a proxy measure for SUD) exist between Lphn3 KO and WT rats.