Finally, the survival analysis of these 15 hub mRNAs showed that the high expression of 14 hub mRNAs (H2AFZ, HNRNPA1, RAN, SNRPD1, H2AFX, NASP, PPIA, CSNK1D, NAP1L1, DARS2, FARSB, SMARCC1, TPM3, and ZCCHC17) was related to the poor prognosis of patients with HCC. This evidence concerns the gene CSNK1D and hepatocellular carcinoma.