Finally, the survival analysis of these 15 hub mRNAs showed that the high expression of 14 hub mRNAs (H2AFZ, HNRNPA1, RAN, SNRPD1, H2AFX, NASP, PPIA, CSNK1D, NAP1L1, DARS2, FARSB, SMARCC1, TPM3, and ZCCHC17) was related to the poor prognosis of patients with HCC. The gene discussed is ZCCHC17; the disease is hepatocellular carcinoma.