In addition, SOX10 mutations can induce Kallmann syndrome (KS, OMIM 308700) as well a plethora of neurological symptoms in the neural crest (PCWH), such as outer peripheral demyelinating neuropathy, central myelination disorder, WS, and Hirschsprung’s disease (HD) (Pingault et al., 2000, 2013; Inoue et al., 2004). Here, SOX10 is linked to Werner syndrome.