Indel deletion alterations of the AXIN1 gene were noted in 1 patient with chronic hepatitis B. It is interesting to note that 1 patient presented with single nucleotide variations of APC, insulin like growth factor 2 (IGF2), dicer 1, ribonuclease III (DICER1), notch receptor 1 (NOTCH1) and phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta (PIK3C2B) genes. The gene discussed is NOTCH1; the disease is chronic hepatitis B virus infection.