Collectively, these findings make sense considering that obesity promotes white adipose tissue dysfunction [40], which then orchestrates many cellular responses: increased secretion of proinflammatory mediators such as TNF-α and IL-6 [41], overproduction of leptin by adipocytes [35], and over activation of transcription factors [15, 17, 35]. The gene discussed is LEP; the disease is obesity due to melanocortin 4 receptor deficiency.