The results confirmed that dietary protein and fish oil have protective effects against the development of T2D and NAFLD by downregulating miR-411 (>8-fold decrease by high glucose treatment of endothelial cells), miR-155 and miR-335 (>2-fold decrease by suppressing inflammation), miR-21 (>2-fold decrease as a marker of NAFLD by targeting HMGCR expression), miR-143 (>2-fold decrease by targeting the oxysterol-binding protein-related protein 8 (ORP8)), and miR-29a,b,c (>2-fold decrease by targeting FOXA2) [154]. The gene discussed is HMGCR; the disease is metabolic dysfunction-associated steatotic liver disease.