PNPLA3 and metabolic dysfunction-associated steatotic liver disease: Some of these genes (lipid biosynthetic regulating transcription factors, nuclear receptors, fibrogenesis, and inflammatory response factors) are involved in NAFLD genetic susceptibility [9], for instance, the NLR family pyrin domain-containing 6 (NLRP6), NLR family pyrin domain-containing 3 (NLRP3), and interleukin-18 (IL-18) genes' expression or SNPs in patatin-like phospholipase domain-containing protein 3 (PNPLA3-rs738409 and rs6006460) [2, 10].