In control, ubiquitin conjugating enzymes UBE2N (Fig. 4A), stress-induced phosphor protein 1 (STIP1) (Fig. 4B) and co-chaperone CDC37 (Fig. 4C) were significantly decreased below baseline from 0.5 to 4-h [UBE2N (RFU): (2931.4 ± 121.4 vs 3912.5 ± 267.2, 0.5-h post-hypoglycemia vs baseline, p < 0.01; 2973.2 ± 151.4 vs 3912.5 ± 267.2, 1-h post-hypoglycemia vs baseline, p < 0.01; 2983.3 ± 190.4 vs 3912.5 ± 267.2, 2-h post-hypoglycemia vs baseline, p < 0.01; 2905.3 ± 227.2 vs 3912.5 ± 267.2, 4-h post-hypoglycemia vs baseline, p < 0.01. The gene discussed is STIP1; the disease is Hypoglycemia.