The pro-inflammatory cytokine, IL-6, increased at 4-h post-hypoglycemia in controls and T2D (p < 0.05 and p < 0.003, baseline vs 4-h, respectively) whilst the anti-inflammatory cytokine, IL-10, decreased 2-h post-hypoglycemia in T2D (p = 0.0001, baseline vs 2-h). Here, IL10 is linked to type 2 diabetes mellitus.