In conclusion, heat shock and related proteins differed at baseline between T2D and controls with an exaggerated response of heat shock and related proteins to hypoglycemia that returned to baseline, though with changes in heat shock and related proteins at 24-h, where an increase in pro-inflammatory interleukin-6 was seen, suggesting that the heat shock and related protein system is overactivated due to underlying inflammation and oxidative stress in T2D. Here, IL6 is linked to Hypoglycemia.