SMAD3 and type 2 diabetes mellitus: In T2D, following hypoglycemia, SMAD3 was higher than baseline at 2-h (5369.6 ± 245.5 vs 4399.1 ± 152.8 RFU of SMAD3, 2-h post-hypoglycemia vs baseline, p < 0.01) (Fig. 5A).