Review of the overall trends of the heat shock response and related proteins in response to hypoglycemia in T2D and controls showed there were a group of heat shock and related proteins that, overall, tended to be consistently higher in T2D compared to controls (CLU, SMAD3, HSP90ab, CDC37, HSPA8 (co-chaperone 70), STIP1, DNAJB1, UBE2L3, UBE2N, UBE2G2); only 1 protein was consistently lower in T2D (STUB1) whilst a group of heat shock and related proteins appeared to show no difference in trend between T2D and controls (MAPKAPK5, PPP3CA, HSPB1, HSPA1A, EPHA2, HSPD1). The gene discussed is CLU; the disease is type 2 diabetes mellitus.