Why the levels of UBE2N, UBE2L3 and STIP1 should fall in the control subjects in response to hypoglycemia, whilst UBE2G2 showed no apparent change in level, is unclear, and whether the loss of regulation of these specific and tightly controlled proteins would lead to a detrimental effect is unknown. The gene discussed is UBE2G2; the disease is Hypoglycemia.