SMAD3 and Hypoglycemia: SMAD3 was higher at 1 h and 2 h post-hypoglycemia in T2D compared to control (4696.5 ± 371.1 vs 3870.1 ± 132.0, 1 h post-hypoglycemia, p < 0.05; 5369.6 ± 245.5 vs 4545.1 ± 211, 2 h post-hypoglycemia, p < 0.05).