Notably UBE2N, UBE2L3, and STIP1 all significantly go down in controls but not at all in T2D in response to hypoglycemia, whilst the protein that is linked within the system, UBE2G2, was unaffected by hypoglycemia, though significantly lower than levels seen in T2D at all time points. Here, UBE2N is linked to type 2 diabetes mellitus.