In T2D, the level of PPP3CA was increased (532.1 ± 34.1 vs 448.3 ± 25.4 RFU of PPP3CA, hypoglycemia vs baseline, p < 0.05 (Fig. 3E) and the level of EPHA2 was decreased (2178.0 ± 73.0 vs 2425.1 80.0 RFU of EPHA2, hypoglycemia vs baseline, p < 0.05) (Fig. 3F) from baseline to hypoglycemia in T2D, though both returned to baseline values 0.5-h after the hypoglycemic episode. Here, PPP3CA is linked to type 2 diabetes mellitus.