For those HSPs that generally show a suggested trend to be consistently higher in T2D in Figs. 2, 3, 4 and 5, these graphs are not shaded (CLU, SMAD3, HSP90ab, CDC37, HSPA8 (co-chaperone 70), STIP1, DNAJB1, UBE2L3, UBE2N, UBE2G2); for the single HSP (STUB1) that is generally lower in T2D than controls, this graph is shaded in yellow; for those HSPs that appeared to show no difference in trend between T2D and controls (MAPKAPK5, PPP3CA, HSPB1, HSPA1A, EPHA2, HSPD1), these graphs are shown in blue. The gene discussed is UBE2L3; the disease is type 2 diabetes mellitus.