Review of the overall trends of the heat shock response and related proteins in response to hypoglycemia in T2D and controls showed there were a group of heat shock and related proteins that, overall, tended to be consistently higher in T2D compared to controls (CLU, SMAD3, HSP90ab, CDC37, HSPA8 (co-chaperone 70), STIP1, DNAJB1, UBE2L3, UBE2N, UBE2G2); only 1 protein was consistently lower in T2D (STUB1) whilst a group of heat shock and related proteins appeared to show no difference in trend between T2D and controls (MAPKAPK5, PPP3CA, HSPB1, HSPA1A, EPHA2, HSPD1). This evidence concerns the gene MAPKAPK5 and Hypoglycemia.