Moreover, IgA, IgG, and IgM levels in the LGIN group was slightly lower than in the normal and esophagitis group, which indicated that a worse immune dysfunction in the LGIN group after knowing the screening diagnosis, which indicated that screening and diagnosis were potentially detrimental to participants by invading the neuroendocrine-immune function through the hypothalamic–pituitary–adrenal axis (HPA). This evidence concerns the gene CD40LG and esophagitis.