It has previously been shown to play a crucial role in DNA damage response and to be a major cell fate regulator in tumor cells through its role as a regulator of p53 and p21WAF1 activities, whereby its suppression leads to apoptosis, its moderate upregulation results in growth arrest, and its excessive increase induces increased proliferation and malignant transformation31–34. The gene discussed is TP53; the disease is neoplasm.