CRH and Anxiety: The BNST is enriched with neurons that synthesize and release corticotropin-releasing factor (CRF), a stress neuropeptide involved in the development and maintenance of anxiety and addictive disorders, and activation of BNSTCRF neurons drives binge drinking behavior and produces anxiety9,10; however, the identity and organization of upstream excitatory circuits controlling BNSTCRF neuron function and its role in alcohol drinking and anxiety are poorly understood.