Based on the analysis of GEPIA database, our observed that ADAM15 expression was markedly different in CD4 T cells, NK cells, Monocytes, Macrophage M0, Macrophage M1, Macrophage M2, B naive cells, CD8 T cells, Dendritic cells and Neutrophils of HCC tissues (P < 0.05) (Supplementary Figure 2A, 2C). This evidence concerns the gene CD4 and hepatocellular carcinoma.