CD4 and neoplasm: As shown in Figure 4A, ADAM15 expression was negatively associated with tumor purity (cor = –0.112, P = 3.81e-02), and was positively correlated with B cells (cor = 0.2, P = 1.85e-04), CD8+T cells (cor = 0.178, P = 9.38e-04), CD4+T cells (cor = 0.307, P = 6.30e-09), Macrophages (cor = 0.271, P = 3.69e-07), Neutrophils (cor = 0.379, P = 3.11e-13) and Dendritic cells (cor = 0.278, P = 1.88e-07), of which ADAM15 had the strongest correlation with Neutrophils.