The recognition that NER genes including XPC, XPA, XPD, CSA, CSB, and XPG possess HREs prompted us to interrogate whether hyperglycemia-induced destabilization of HIF-1α contributed to NER attenuation (Filippi et al, 2008; Rezvani et al, 2010; Liu et al, 2012). The gene discussed is ERCC5; the disease is Hyperglycemia.