IGFBP5 and polycystic ovary syndrome: There is evidence that miR-93 has a role in processes related to T2DM, including insulin resistance and subsequent polycystic ovarian syndrome [25], and a prior genome-wide association study found an association between insulin like growth factor binding protein 5 (IGFBP5), which is a mRNA target of miR-197, and adipose tissue volume in women.