To test whether Wnt antagonists could alter the vascular phenotype of DMG tumor models we expressed the Wnt receptor antagonist Dkk1, or a secreted version of the Fzd8 receptor (Fzd8-CRD-IgG) [43] in our IUE DMG mouse model (Additional file1: Fig. S6). Here, DKK1 is linked to neoplasm.