ESR1 and endometriosis: In a mouse endometriosis model, bazedoxifene [139], an estrogen receptor modulator, administered with the conjugated estrogens and letrozole [143] (aromatase inhibitor) not only alleviated the lesions of endometriosis, but also dramatically reduced the recruitment of BMDSCs to the lesions and restore the stem cell engraftment of the uterine endometrium.