TAT and brain ischemia: Furthermore, Li found that, in the repeat III domain of Nuclear translocation of annexin A1(ANXA1) which participant in the neuronal apoptosis after cerebral ischemia, function as a unique nuclear translocation signal (NTS) and are required for nuclear translocation of ANXA1.The synthesized peptide Tat-NTS containing the NTS sequence of ANXA1 and the HIV-Tat cell transduction domain will specifically disrupt the interaction between ANXA1 and importin β, thereby inhibiting the nuclear translocation of ANXA1, protecting neurons from ischemic stroke deficiency.