It has been reported that LILRB4 are involved in the pathogenesis of various diseases such as allergic diseases [9, 10], acute lung injury [11], cancer [12–15], autoimmune diseases [16], transplantation immunity [17, 18], nonalcoholic fatty liver disease [19], and infection disease [20]. This evidence concerns the gene LILRB4 and metabolic dysfunction-associated steatotic liver disease.