It was confirmed that the SGLT2 gene and protein expression amounts were significantly stronger in LPS-STZ than in LPS-ICR and in STZ-ICR (Fig. 1B), and there were no differences in the SGLT2 production of LPS-ICR and STZ-ICR, suggesting that P. gingivalis infection is the cause of the renal overexpression of SGLT2 under diabetic conditions, and that the SGLT2 overexpression does not occur only with one of diabetes or Pg-LPS. The gene discussed is SLC5A2; the disease is diabetes mellitus.