PROS1 and nephrotic syndrome: The pathophysiology of hypercoagulability in the nephrotic syndrome is due to imbalances of prothrombotic and antithrombotic factors, impaired thrombolytic activity, and other important contributing factors such as intravascular volume depletion, the use of diuretics, immobilization, and procoagulant diatheses (such as protein C and protein S deficiencies) [7].