CD47 and infection: Importantly, we found that macrophage infection was generally more efficient upon coculture with T cells infected with WT WITO than upon coculture with T cells infected with Vpu-deficient WITO (Fig. 5C), thus supporting the notion that enhanced phagocytosis of infected T cells by MDMs following Vpu-mediated CD47 downregulation promotes a heightened productive infection of MDMs.