Taking advantage of a Jurkat cell line expressing human-mouse chimeric CD47, which is relatively unresponsive to Vpu modulation (Fig. S6; Fig. 7A and B), we validated that Vpu-mediated CD47 downregulation contributes to phagocytosis of HIV-1-infected CD4+ T cells by MDMs and facilitates productive infection of MDMs (Fig. 7C and D). The gene discussed is CD4; the disease is infection.