Considering that a higher MD represents a higher degree of homeostasis lost, this finding could signify that once homeostasis regulation is lost, clinical and biochemical risk factors for T2D with sexual dimorphism, such as the higher body fat percentage, fetuin-A, a protein secreted primarily by the liver that regulates insulin signaling [54], neurotensin, a neuro peptide associated with satiety and gut motility [55], sex hormone–binding globulin [56], among others, may exert a major effect. Here, INS is linked to type 2 diabetes mellitus.