2018). In the current study, we found that in the components of the non-canonical Wnt signalling pathway, including Wnt-4/-5A/-5B, FZD-2/-3 expression levels were significantly reduced after YGJ treatment. As such, YGJ may have a regulatory effect on the activation of Wnt signalling in liver fibrosis induced by 2-AAF/CCl4 in rats. The gene discussed is FZD2; the disease is Hepatic fibrosis.