NF2 and neoplasm: To study how Merlin selectively induced growth arrest in Merlin-deficient cells and shed light on Merlin-regulated genes, we analysed by microarray global gene expression after expressing either Merlin wt or an inactive L46R mutant that is unable to interact with the PAFC (Fig 2D) in a set of four cell line pairs derived from different tumour types (S2C Fig).