Regardless, their association with renal defects may provide an independent genetic link: in addition to cancer, FAT1 mutations are linked to glomerulotubular nephropathy and fat1 knockdown in zebrafish causes pronephric cysts [74, 75] whereas CDC73 mutations in HPT-JT syndrome are associated with renal lesions in 20% of cases, most commonly cysts [76]. The gene discussed is FAT1; the disease is cancer.