For this, we have identified 15 proteins that were unique or most highly upregulated at the moment of diagnosis (before treatment, S0) as predictive biomarkers of severe PS development in PCM, as following: 60S ribosomal protein L7-like 1, angiotensinogen, complement C5, putative uncharacterized protein MYH16, shieldin complex subunit 3, hemoglobin subunit beta, hemoglobin subunit gamma-2, hemoglobin subunit delta, hemoglobin subunit epsilon, hemoglobin subunit gamma-1, hemoglobin subunit alpha, alpha-enolase, gamma-enolase, beta-enolase, transthyretin. The gene discussed is ENO3; the disease is paracoccidioidomycosis.