With regard to the correlation between biomarkers and clinical features, FN1 and C3 were found to be significantly negatively correlated with GFR in DN glomerulus (r = −0.68, p = 4.94E-4 and r:-0.58, p = 0.005) and tubule (r = −0.755,p = 4.95E-5 and r = −0.842, p = 8.95E-7) samples based on Woroniecka diabetes data in the Nephroseq platform, suggesting a pathogenic role of biomarkers (Figure 9(a), 9(d); Figure 9(b, 9(e)). The gene discussed is C3; the disease is diabetes mellitus.