APP and Alzheimer disease: Compared with Control, the expressions of App, p-Tau and Bace-1 were greatly upregulated by Aβ25-35, while CPT1C overexpression reversed the promotive effects of Aβ25-35 on deposition of AD marker proteins, evidenced by the downregulated expressions of App, p-Tau and Bace-1 in contrast with Aβ25-35 + Ov-NC (Figure 5(a,b)).