APOE and Alzheimer disease: Of note, there have been similar race/ethnicity findings for the association of APOE ɛ4 with Alzheimer disease.32 Among White and Hispanic patients, both homozygous and heterozygous APOE ɛ4 were associated with Alzheimer disease, whereas among Black participants, this association was only present for homozygous APOE ɛ4.