TLR4 engagement on mouse FDCs induces up-regulation of Fc receptors and integrins, while TLR7 on FDCs promotes auto-reactive B cells in a mouse model of systemic lupus erythematosus through secretion of IFN-α (Das et al., 2017; El Shikh et al., 2007). The gene discussed is TLR7; the disease is systemic lupus erythematosus.