CD8A and COVID-19: When comparing this pathway between disease groups in all T and NK cell clusters, we found this pronounced type I interferon signature among virtually all clusters in patients with COVID-19, particularly in the EMRA-like T cell clusters and both NK cell clusters (Figure 4g,h, statistically significant in the CD8 EMRA-like 2 and granulysin+ NK cell clusters, two-sided Kruskal-Wallis test with post hoc Dunn’s test BH-adjusted p<0.05).