In chicken DT40 cells, knock‐out of H2A.Z.2 results in a slower cell proliferation rate compared with the wild‐type and H2A.Z.1 knock‐out cells (Matsuda et al, 2010), while in humans, the Floating‐Harbor syndrome (Greenberg et al, 2019) and malignant melanoma (Vardabasso et al, 2015) have been specifically linked to H2A.Z.2 (Greenberg et al, 2019). The gene discussed is H2AZ1; the disease is melanoma.